Cambridge IGCSE · Topic 17.3
IGCSE Biology 0610 / Topic 17 / IGCSE

Halving the number, shuffling the set.

Gametes are not made by mitosis. Sperm and eggs are made by meiosis, a different kind of nuclear division. Extended: meiosis is a reduction division that halves the chromosome number from diploid to haploid and makes gametes that are genetically different from each other.

The key idea

Meiosis is involved in the production of gametes. Extended: it is a reduction division in which the chromosome number is halved from diploid to haploid, resulting in genetically different cells.

diploid cell 4 chromosomes (2 pairs) meiosis 4 haploid gametes, 2 chromosomes each reduction division: diploid → haploid, genetically different
Fig. 1: meiosis turns one diploid cell into four haploid gametes, each with one chromosome from each pair
Section 01

Making gametes.

The sim cell is in an ovary or testis. Red chromosomes came from the mother and blue from the father. Press Next step to the end, then press Start again and repeat: compare the gametes each time.

Examiner trap

Haploid does not mean half a chromosome or half of each chromosome. It means a single set: one whole chromosome of each type.

Stage 1 · Learn

Check what the sim just showed you

Four quick checks. Each correct answer earns XP and records this skill on your profile.

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In the sim, how many chromosomes does each gamete have at the end?

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How many gametes are made from the one cell in the sim?

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You press Start again and run meiosis twice. Why do the gametes contain different mixtures of red and blue chromosomes?

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Extended: what happens at the step First division in the sim?

Section 02

Mitosis or meiosis?

Many exam questions ask you to compare the two divisions. The key differences are where they happen, how many chromosomes the new cells get and whether the cells are identical.

MitosisMeiosis
Used forgrowth, repair, replacement, asexual reproductionmaking gametes
Chromosome number in new cellsthe same as the parent cell (diploid stays diploid)halved (diploid to haploid)
New cells are geneticallyidenticaldifferent
Human exampleskin cell, 46 → 46cell in testis, 46 → sperm, 23
Examiner trap

The zygote divides by mitosis, not meiosis. Meiosis happens only when gametes are being made.

Stage 2 · Exam

Exam-style questions

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Meiosis is involved in the production of:

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Extended: a dog has 78 chromosomes in its body cells. How many are there in a dog sperm?

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Extended: which statement describes meiosis?

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Extended: why is it important that gametes are haploid?

Skill unlocked

Meiosis, mastered.

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Go deeper · practice
Six original Cambridge-style questions
Meiosis and gamete production and (Extended) reduction division, haploid and diploid, and genetically different gametes, compared with mitosis.